Leptin increases growth of primary ossification centers in fetal mice
نویسندگان
چکیده
منابع مشابه
Relationship between concentration of serum leptin and fetal growth.
The serum leptin concentration reflects the amount of adipose tissue in the body. Although fat deposition in the fetus in the third trimester markedly increases, the role of leptin during pregnancy has not been clarified. In the present study, whether or not the serum leptin concentration correlates with growth in utero was investigated, in addition to how leptin levels change in the first few ...
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Provision of the maternal factors, albumin and/or insulin to embryos in vitro restores preimplantation morphological development and cell proliferation to that seen in vivo. The hypothesis that the preimplantation effects of insulin or albumin would be reflected in increased fetal growth rate was examined. Two-cell embryos were cultured 48-50 h in medium supplemented with 0.17 micromol/l, 15 mi...
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Peripheral and central leptin administration have been shown to mediate central dopamine (DA) signaling. Leptin-receptor deficient rodents show decreased DA D2 receptor (D2R) binding in striatum and unique DA profiles compared to controls. Leptin-deficient mice show increased DA activity in reward-related brain regions. The objective of this study was to examine whether basal D2R-binding differ...
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The role of PI3K in leptin physiology has been difficult to determine due to its actions downstream of several metabolic cues, including insulin. Here, we used a series of mouse models to dissociate the roles of specific PI3K catalytic subunits and of insulin receptor (InsR) downstream of leptin signaling. We show that disruption of p110α and p110β subunits in leptin receptor cells (LRΔα+β) pro...
متن کاملRadiological and Histological Assessment of the Ossification Centers of Pectoral Limb in Quail
BACKGROUND: The growth and differentiation of skeletal pectoral limb girdle, wing and the ossification centers in these regions after hatching were investigated in some groups of quails. OBJECTIVES: The aim of this study was to determine the age of physical maturity and radiological and histological assessment of the ossification centers of pectoral limb in quail. METHODS: 14 quails after hatch...
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ژورنال
عنوان ژورنال: Journal of Anatomy
سال: 2009
ISSN: 0021-8782,1469-7580
DOI: 10.1111/j.1469-7580.2009.01134.x